Every Friday through April, join the Problems in Complex Disease Biology Colloquium Series.
Please join Cathryn Nagler, PhD, for her lecture titled "Regulation of Allergic Responses to Food by Intestinal Bacteria.”
This week, the exciting ride through the bacterial facet of the microbial world will become — if possible — even more exciting when Dr. Nagler will discuss the growing evidence linking food allergy (now considered by many to be a disease of epidemic proportions) to the composition and function of intestinal microbes. She will present microbial therapies that are currently under development to address this ever-growing, serious problem, thus showing how cutting-edge microbiome research can be translated into biomedical applications.
All of this would be interesting and timely enough to explain why it's so pleasing to have Dr. Nagler among the course's speakers. But there is another, more fundamental reason: the unique experimental angle she brings to the colloquium. Both Jack Gilbert and Sue Lynch, the previous microbiome speakers, have alluded multiple times to the extraordinary power that germ-free mouse models have to highlight the mechanistic relations between microbes and traits. Relying on her mouse immunology background and the outstanding infrastructure provided by the University of Chicago, Dr. Nagler is among the few who have mastered the difficult art of using these models to understand the impact of microbiota on immune responses. She is seeking to come full circle and move from humans (children with food allergy and their gut microbes) to germ-free mice associated with these microbes or healthy ones, and back to humans who may one day be treated with the protective microbes she is identifying.
This transformational paradigm is becoming increasingly pervasive in so many fields. Thus, it will be a privilege to have this groundbreaking work presented by one of the scientists who are leading the charge.