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Dissecting the Molecular Mechanisms of TRPV1 Polymodal Regulation

Dec
02
3:30 pm to 4:30 pm
Department of Chemistry and Biochemistry Logo

Transient receptor potential (TRP) ion channels function in diverse physiological roles. Some TRP channels are directly activated by temperature. These include TRPV1 and TRPM8, which are canonical human heat and cold sensors respectively. Both channels are also relevant to pain-sensing. Despite significant clinical trials, drug discovery efforts to develop TRPV1 antagonists have generally failed due to on-target adverse effects in thermosensing and thermoregulation. Clinical failures are thought to arise from inherent polymodal regulation, where diverse mechanisms; including, temperature, chemical ligands and pH activate TRPV1. Using electrophysiology-based cellular studies coupled with temperature-dependent solution NMR spectroscopy and other biophysical tools, we’ve made progress in disentangling these mechanisms and identifying the molecular underpinnings of thermosensing. This presentation will detail our multidisciplinary efforts to understand TRP channel polymodal regulation and allosteric networks.

Zoom passcode: UACBC

Wade Van Horn, PhD
Wade Van Horn, PhD
Associate Professor
School of Molecular Sciences, Arizona State University
To request any disability-related accommodations for this event please contact the event coordinator at least three business days prior to the event.
Dec
02
3:30 pm to 4:30 pm
Thursday, December 2, 2021 - 3:30pm
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AUDIENCE

Faculty, Staff, Students, Alumni, Community
University of Arizona Health Sciences

LOCATION

Tucson area
Virtual
Main Campus – Tucson
Henry Koffler Building
Room 218
1340 E University Blvd, Tucson AZ 85721

CONTACT

Ellie Warder
College of Medicine – Tucson
Department of Chemistry and Biochemistry