Friday Frontiers in Biomedical Science
Friday Frontiers in Biomedical Science is designed to engage researchers and clinicians at all stages of career development. This session features University of Arizona College of Medicine – Tucson associate professor of immunobiology, Michael D. L. Johnson, PhD, and associate professor of pediatrics, Daniel J. Moore, MD, PhD from Vanderbilt University. The two speakers will share a 20-minute overview of their work, with an opportunity for audience engagement. Light refreshments will be provided.
Title: Exploiting antimicrobial properties of copper as a therapeutic
Dr. Johnson in an associate professor of immunobiology, member of the UArizona BIO5 Institute and director of the National Summer Undergraduate Research Project. Dr. Johnson's research investigates the role of metals as cofactors or structural components that compose roughly 40% of all proteins. His laboratory investigates how bacteria maintain homeostasis within the metal milieu. Dr. Johnson's research also determines how metals are processed, the orchestrated response during metal sensing and the role that the host plays in this process during infection. Understanding how bacteria interact with metals during infections will identify novel therapeutic strategies against bacterial infections.
Title: Insights into the pathogenesis and prediction of Type 1 diabetes progression
Dr. Moore is an associate professor of pediatrics and the director of the Fellowship in Pediatric Endocrinology at Vanderbilt University. Dr. Moore's research seeks to understand the cellular and molecular mechanisms that govern immune tolerance in order to prevent and reverse Type 1 diabetes and enhance the success of organ transplantation. This research formed part of the foundation for current efforts to use B cell directed therapies to prevent diabetes, studies in which Vanderbilt is participating through the Type 1 diabetes TrialNet where Dr. Moore is a co-investigator. He is presently extending these studies to understand how B lymphocytes control immune tolerance to transplants and how this cell type participates in broken tolerance in autoimmune disease such as Type 1 diabetes.