Influenza and SARS-CoV-2 Surveillance and the Identification of Novel Genetic Mutations that Facilitate Virus Circulation
The Department of Immunobiology presents: "Influenza and SARS-CoV-2 surveillance and the identification of novel genetic mutations that facilitate virus circulation"
The Pekosz Lab studies respiratory viruses through a variety of perspectives.
As part of the CEIRR network, they conduct seasonal Influenza and SARS surveillance in Baltimore, Taiwan, and Macha (Zambia). As part of their surveillance work, they characterize and sequence variant viruses as they arise in populations.
They conduct research on the viral and host factors that contribute to temperature-dependent SARS-CoV-2 and influenza replication using human nasal epithelial cell culture model systems (hNEC). Their research on viral and host factors includes investigations of mitochondrial dynamics, single-cell transcriptional responses, and IgG and IgM production in hNECs.
They evaluate live attenuated influenza vaccines (LAIVs) and come up with strategies for improvement and perform serology work focused on convalescent plasma and immune evasion.
Additionally, they investigate temperature-dependent strain variability in enterovirus D68.
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