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Pharmacology Seminar Series | Synaptic Defects in Mouse Models of Dystroglycanopathy

11:00 am to 12:00 pm
College of Medicine – Tucson Department of Pharmacology logo

Please join us for our next Pharmacology Seminar Series: “Synaptic defects in mouse models of dystroglycanopathy”

Abstract: Dystroglycan is a heavily glycosylated transmembrane protein that links the extracellular environment to the actin cytoskeleton. Defects in dystroglycan function cause a form of congenital muscular dystrophy (dystroglycanopathy) that is often accompanied by neurological dysfunction. Using multiple mouse models of dystroglycanopathy, we have identified a critical role for dystroglycan in regulating the formation and maintenance of subsets of inhibitory synapses in the brain. Our results show that dystroglycan's synaptic function requires both proper glycosylation and its intracellular domain, and that the degree of dysfunctional glycosylation correlates with synaptic defects and seizure susceptibility

Photo of Kevin Wright, PhD
Kevin Wright, PhD
Associate Professor
Vollum Institute - Oregon Health & Science University
To request any disability-related accommodations for this event please contact the event coordinator at least three business days prior to the event.
11:00 am to 12:00 pm
Wednesday, February 1, 2023 - 11:00am
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Faculty, Staff, Students, Community
College of Medicine – Tucson


Tucson area
Health Sciences – Tucson
Arizona Health Sciences Center
Room 8403
1501 N. Campbell Ave., Tucson, AZ 85724


Vickie Healey
College of Medicine – Tucson
Department of Pharmacology