Is a Moderna, Pfizer or J&J Covid-19 Booster Shot Best for You? What to Know About Mixing Vaccines

Evidence that the Moderna vaccine produces a higher level of antibodies than the Pfizer vaccine might give it an edge as a booster, some scientists say. Yet some people experience more side effects with Moderna, albeit mostly moderate ones, such as fatigue, muscle aches and chills. And the antibody difference between Pfizer and Moderna isn’t huge. “From the data we’ve got, Moderna is doing a touch bit better,” says Deepta Bhattacharya, PhD, a professor of immunobiology at the College of Medicine – Tucson. “We’re not talking orders of magnitude.”