Extracellular matrix - integrin axis contributes to insulin resistance

Endocrinology Grand Rounds

When

3 to 4 p.m., Dec. 12, 2023

Where

Arizona Health Sciences Center, Room 5403
1501 N. Campbell Ave. Tucson, AZ. 85724

or

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Outcome Objectives: 

  • Extracellular matrix is inversely related to insulin sensitivity.
  • Obesity leads to ECM expansion and activation of integrin heterodimeric receptors.
  • Integrin-linked kinase contributes to fatty liver and impairs suppression of glucose production.

Presenter Details:

David H. Wasserman, PhD
Professor of Molecular Physiology and Biophysics
AM Lyle Professor of Biomedical Research

Wasserman is a professor of molecular physiology and biophysics and AM Lyle Chair of Biomedical Sciences at Vanderbilt University. Wasserman has been director of the NIDDK Vanderbilt Mouse Metabolic Phenotyping Center since its inception in 2001 and on the executive committee of the Vanderbilt Diabetes Research and Training Center since 2007. Wasserman is co-director of the MMPC Course entitled “Glucose Clamping the Conscious Mouse” which is now in its 22nd edition. He is a recipient of the Bowditch Award and the Solomon Berson Award of the American Physiological Society, an NIH MERIT Award, the C.R. Park Award for Excellence in Research, and the John H. Exton Award for Research Leading to Innovative Biological Concepts.