College of Medicine – Tucson Department of Pharmacology
When
Where
Arizona Health Sciences Center, Room 8403
1501 N. Campbell Ave., Tucson, AZ 85724
Seminar Abstract
Many neurological disorders alter blood-brain barrier and blood-CSF barrier function. There are several barrier-related therapeutic opportunities in neurological diseases. Thus, barrier dysfunction may be the underlying cause of a neurological disorder, or it may exacerbate secondary brain injury (E.g., contributing to brain swelling and neuroinflammation in stroke); ‘enhancing’ barrier function may protect the brain; ‘disrupting’ barrier function can enhance brain drug delivery. This talk will discuss such approaches with a particular focus on cerebrovascular diseases. In comparison to brain parenchyma, the brain endothelium and choroid plexus epithelium (blood-CSF barrier) are more accessible to systemically administered therapeutic agents.
Presenter Details
Richard F. Keep, PhD
Director, Crosby Neurosurgical Laboratories
Associate Chair for Research, Neurosurgery
Crosby-Kahn Collegiate Professor of Neurosurgery and Neuroanatomy
Professor, Molecular and Integrative Physiology
University of Michigan
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